Chronic naltrexone treatment increases expression of preproenkephalin and preprotachykinin mRNA in discrete brain regions
A Tempel, JA Kessler, RS Zukin - Journal of Neuroscience, 1990 - Soc Neuroscience
Long-term blockade of brain opioid receptors by the opiate antagonist naltrexone increases
methionine-enkephalin content in the striatum and nucleus accumbens (Tempel et al.,
1984). To determine whether these changes in peptide levels reflect increased peptide
synthesis, we examined preproenkephalin mRNA content in discrete brain regions of control
(placebo-treated) and chronic naltrexone-treated animals by Northern analysis. Chronic
naltrexone treatment (8 d) led to an approximately 12-fold increase in the striatal content of …
methionine-enkephalin content in the striatum and nucleus accumbens (Tempel et al.,
1984). To determine whether these changes in peptide levels reflect increased peptide
synthesis, we examined preproenkephalin mRNA content in discrete brain regions of control
(placebo-treated) and chronic naltrexone-treated animals by Northern analysis. Chronic
naltrexone treatment (8 d) led to an approximately 12-fold increase in the striatal content of …
